Abstract 15458: Prevalence and Burden of Abdominal Aortic Plaque Are Inversely Associated With Kidney Function: the Framingham Heart Study
Background: We sought to determine whether renal function as assessed by estimated glomerular filtration rate (eGFR) is independently associated with atherosclerotic abdominal aortic plaque (AAP).
Methods: 1726 adults (65±9y, 53% women) from the Framingham Offspring cohort underwent cardiovascular magnetic resonance (CMR) abdominal imaging (axial T2W black-blood); prevalence and volume of AAP were quantified. Serum creatinine was measured at the adjacent cycle visit and eGFR was calculated using Chronic Kidney Disease Epidemiology Collaboration equations. We determined prevalence and volume of AAP by sex-specific quartiles of eGFR and tested for trend (Cochrane-Armitage) across quartiles. Multivariable-adjusted logistic regression models were used to determine odds of AAP per 10 units of eGFR.
Results: For the entire group, eGFR was 84±18 ml/min/1.73m2 and did not differ between sexes. AAP prevalence decreased with increasing eGFR quartile in both sexes (Figure, top): p for trend <0.0001 in men, p=0.0006 in women. Considering only study participants with AAP>0, mean volume of AAP decreased (Figure, bottom) with greater eGFR quartile in both sexes, p<0.0001 for men, p=0.004 for women. Trends remained significant when all study participants (including those with AAP=0) were analyzed. On logistic regression analyses every 10 units of eGFR decreased odds for prevalent AAP by 0.90 (95% confidence intervals 0.84 - 0.97) after adjustment for age, sex and traditional cardiovascular disease (CVD) risk factors; in the same model greater age (OR=1.28 per 10y; 1.10 - 1.48), smoking (OR=1.80; 1.24 - 2.62), and cholesterol treatment (OR=1.50; 1.12 - 2.02) were also associated with greater prevalence of AAP.
Conclusion: Prevalence and burden of AAP both increase with decreasing eGFR in a community dwelling cohort of adults. Greater eGFR is independently associated with decreased prevalence of CMR-detected AAP even after adjustment for traditional CVD risk factors.
Author Disclosures: M.L. Chuang: None. P. Gona: None. N. Oyama-Manabe: None. D.A. Roseman: None. G.M. McMahon: None. C.J. Salton: None. C.J. O’Donnell: None. C.S. Fox: None. W.J. Manning: None.
- © 2014 by American Heart Association, Inc.