Abstract 15409: Carotid Vascular Strain Predicts Cardiovascular Events in Treated Hypertension
Introduction: Our previous study has shown carotid deformations were associated with stroke. However, the prognostic impact of carotid deformations in patients with hypertension is unknown.
Hypothesis: Carotid deformation parameters can be used as prognostic factors in hypertension.
Methods: We prospectively recruited 120 regularly treated hypertensive patients (65.8 ± 11.8 years, 58% male) in this observational study. Carotid deformation indexes including peak circumferential strain (CS) and peak strain rate (CSR) after ejection were identified using the two-dimensional speckle tracking echocardiography. Average of bilateral CS and CSR of carotid arteries were used for analysis. Cardiovascular events as end-points for this study included any admission for stroke, acute coronary syndrome, heart failure, and cardiovascular death.
Results: After a mean follow-up period of 40.7 ± 26.4 months, 14 (12%) patients reached end-points. Age (75.3 ± 9.2 vs. 64.6 ± 11.6 years; p = 0.001), systolic blood pressure (132 ± 16 vs. 143 ± 17 mmHg; p = 0.021), central systolic blood pressure (114 ± 14 vs. 129 ± 21 mmHg; p = 0.019), diuretics usage (33 vs. 9 %; p = 0.014), carotid CS (2.17 ± 1.02 vs. 3.28 ± 1.14 %; p = 0.001), and CSR (0.28 ± 0.17 vs. 0.51 ± 0.18 1/s; p <0.001) were different between patients with and without end-points. Multivariate analysis controlling age, systolic blood pressure, central systolic blood pressure, and diuretics usage showed CS (OR 0.451, 95%CI 0.216-0.941, p = 0.034) and CSR (OR 0.001, 95%CI 0.000-0.146, p = 0.006) were independent predictors for cardiovascular events.
Conclusions: In regularly treated hypertensive patients, decreased carotid strain and strain rate were associated with cardiovascular events. Carotid deformations have prognostic role in hypertension.
Author Disclosures: W. Tsai: None. Y. Sun: None. W. Lee: None. L. Yang: None. Y. Liu: None.
- © 2014 by American Heart Association, Inc.