Abstract 15326: Diastolic Dysfunction in the Hispanic Community: Results from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) Echocardiographic Study of Latinos (ECHO-SOL)
Background: Diastolic dysfunction predicts clinical outcomes and is related to risk factors. However, very little is known regarding the impact of ethnicity on diastolic dysfunction and its relationship to outcomes and risk factors. We propose to assess the HCHS-SOL cohort and investigate Hispanic ethnic differences in the prevalence of diastolic dysfunction.
Methods: The HCHS-SOL prospectively assessed 16,000 Hispanics. We included participants that underwent echocardiograms in the ECHO-SOL ancillary study, excluding participants with current pregnancy, atrial fibrillation, more than mild valvular disease, LVEF <50% or LVEDV >97 ml/m2. Diastolic dysfunction was graded following the algorithm in Figure. Logistic regression models assessed the association of different variables with the presence of diastolic dysfunction. Sampling weights and survey statistics were used for all analyses.
Results: We included 1062 participants; aged 56±3 years, BMI 29±2 g/m2, 65% females, 16% smokers, 43% hypertensives, 69% diabetics/pre-diabetics. Diastolic dysfunction was detected in 58% of Hispanics. Forty-two percent of those without clinical HF had ≥ Grade I diastolic dysfunction (42% with Grade II-III). Compared to Mexicans, Central Americans and Puerto-Ricans had 2-3 fold chance to have diastolic dysfunction (Table).
Conclusion: Diastolic dysfunction is highly prevalent in Hispanics. A significant number of Hispanics without clinical HF have pre-clinical (or unrecognized) diastolic dysfunction. Central American and Puerto-Rican ethnicity appears to pose the highest risk.
Author Disclosures: A.C. Armstrong: None. K. Swett: None. H.J. Mehta: None. D. Kitzman: None. J. Lima: Research Grant; Significant; Toshiba Medical Systems. R. Kaplan: None. S. Shah: None. J. Cai: None. D. Spevack: None. C.J. Rodriguez: None.
- © 2014 by American Heart Association, Inc.