Abstract 15267: Plasma Apelin Level Contributes Exercise Training-induced Improvement of Arterial Stiffness in the Middle and Older Adults
Aging-induced deterioration of arterial stiffness is decreased by regular exercise, and increased nitric oxide (NO) production participates in this effect. Apelin promotes NO production via upregulation of endothelial NO synthase. However, the association between exercise-training effects of arterial stiffness and circulating apelin level in healthy middle-aged and older adults remains unclear.
PURPOSE: This study aimed to determine the time course of changes in plasma apelin level related to exercise-training effects of arterial stiffness in healthy middle-aged and older adults.
METHODS: Thirty-two Japanese healthy middle-aged and older subjects (67 ± 1 years) were randomly divided into two groups: exercise intervention and sedentary controls. Subjects in the training group completed 8-week of aerobic exercise training (60-70% peak oxygen uptake [VO2peak] for 45 min, 3 days/week). VO2peak was measured as an index of cardiorespiratory fitness. We evaluated plasma nitrite/nitrate (NOx) and apelin concentrations and carotid-femoral pulse wave velocity (cfPWV), measured every 2 weeks for 8-week in the training group.
RESULTS: VO2peak was significantly increased after the 8-week intervention. cfPWV was gradually declined from baseline to 8-week and significantly decreased after 8-week intervention (P < 0.05). Plasma NOx level was gradually elevated during exercise intervention and significantly increased from baseline at weeks 6 and 8 (P < 0.05). Interestingly, plasma apelin level was significantly increased from after 4-week intervention (P < 0.05). Additionally, the exercise training-induced reduction in cfPWV was negatively correlated with the percent change in plasma NOx level (r = -0.76, P < 0.001), apelin level (r = -0.54, P = 0.032). Furthermore, there was a positive correlation between the change of plasma NOx level and plasma apelin level (r = 0.60, P = 0.013).
CONCLUSION: These results suggest that the plasma apelin level was increased at the early stage of exercise training intervention and was associated with exercise training-induced alternation of arterial stiffness in the middle and older adults. Thus, plasma apelin level may be a predict biomarker of exercise training-induced improvement of arterial stiffness.
Author Disclosures: S. Fujie: None. K. Sato: None. N. Hasegawa: None. S. Fujita: None. K. Sanada: None. T. Hamaoka: None. M. Iemitsu: None.
- © 2014 by American Heart Association, Inc.