Abstract 15256: Musclular Lipid is Associated With a Risk Factor of Arterial Stiffness
Introduction: Obese and overweight patients increase the risk of arterial stiffness. Visceral fat accumulation may relate to the development of arterial stiffness with enhancing inflammatory cytokine secretion. Additionally, epicardial fat and hepatic fat accumulations are associated with increase in cardiovascular disease risk. Lipids are generally stored in either interstitial adipose tissue (extramyocellular lipid: EMCL) or lipid droplets within muscle cells (intramyocellular lipid: IMCL). Although it is well known that fat accumulation is localized in the whole body and it leads to arterial stiffness, the relationship between IMCL or EMCL contents and arterial stiffness remains unclear.
Pupose: This study aimed to clarify the relationship between IMCL or EMCL contents and arterial stiffness in a cross-sectional study.
Methods: Two-hundred forty five healthy subjects (18-81 years, male: n=141, female: n=104) were enrolled in this study. IMCL and EMCL contents of the right vastus lateralis muscle were evaluated by 1H-magnetic resonance spectroscopy. Arterial stiffness was estimated by using brachial-ankle pulse wave velocity (baPWV).
Results: There were significant correlations between the baPWV and IMCL (r=-0.184, p=0.0038) or EMCL contents (r=0.492, p<0.0001) in all subjects. In female, the baPWV negatively correlated with the IMCL content (r=-0.389, p<0.0001), but there was no significant correlation in male. Nevertheless, significant positive correlation was observed between the baPWV and EMCL content in both male (r=0.475, p<0.0001) and female (r=0.541, p<0.0001). On the basis of multiple regression analyses with 13 independent variable (age, sex, IMCL, EMCL, visceral fat, subcutaneous fat, limb fat mass, blood pressures, lipid profiles, heart rate), IMCL and EMCL contents, age, and systolic blood pressure were independently associated with the baPWV.
Conclusions: These results suggest that IMCL and EMCL contents may be a risk factor of arterial stiffness.
Author Disclosures: N. Hasegawa: None. T. Kurihara: None. K. Sato: None. S. Fujita: None. K. Sanada: None. M. Otsuka: None. T. Hamaoka: None. M. Iemitsu: None.
- © 2014 by American Heart Association, Inc.