Abstract 15188: Coronary Calcium Score and Subclinical Heart Damage: the Multi-Ethnic Study of Atherosclerosis (MESA)
Introduction: Cardiovascular magnetic resonance (CMR) can accurately assess myocardial damage resulting in scar/ fibrosis. The relationship of coronary artery calcium (CAC) score to subclinical myocardial damage is unknown.
Hypothesis: Our aim was to determine the associations between CAC score, cardiovascular disease (CVD) risk factors and myocardial scar in the Multi-Ethnic Study of Atherosclerosis (MESA).
Methods: MESA study is a large population based cohort free of clinical CVD at baseline. In the 10th year of follow up, 1840 participants underwent CMR with gadolinium to evaluate myocardial scar. CVD risk factors including CAC score were measured both at baseline and follow up. Logistic regression models were used to estimate odds ratios (ORs) for scar.
Results: Of 1840 participants (mean age 68±9 yrs, 52% male), 146 had myocardial scars (7.9%). Most myocardial scars (115/146, 79%) were unrecognized by electrocardiogram or clinical assessment. Age and concurrent CAC score were the main predictors of myocardial scar at the 10th year follow up exam (Table). Participants who had CAC scores of 1-99, 100-399 and ≥ 400 at year 10 had 4.1 [1.5-11.3], 6.6 [2.4-18.5] and 7.4[2.6, 20.7] fold higher odds of having myocardial scar compared to those with a zero CAC score after adjustment. The corresponding ORs using the baseline CAC scores were 3.0[1.6, 5.5], 2.7[1.3, 5.6] and 2.4[1.0, 5.7]. Of note, Framingham risk score was not associated with having myocardial scar.
Conclusions: In a community based multi-ethnic cohort, CAC score, age and gender were the main predictors of myocardial scar, suggesting that CAC is associated with myocardial damage.
Author Disclosures: E.B. Turkbey: None. M.S. Nacif: None. M. Guo: None. R. McClelland: None. P.P. Teixeira: None. D. Bild: None. G.R. Barr: None. S.J. Shea: None. W. Post: None. G. Burke: None. M. Budoff: None. A. Folsom: None. C. Liu: None. J.A. Lima: Research Grant; Significant; Toshiba Medical Systems. D. Bluemke: Other Research Support; Modest; Siemens Medical Systems, Philips Medical Systems.
- © 2014 by American Heart Association, Inc.