Abstract 15179: Long Term Prognosis of Intraventricular Conduction Delay in Patients With Structurally Normal Heart
Introduction: Long-term prognosis of nonspecific intraventricular conduction delay(IVCD) remains unclear. This study was performed to elucidate long-term prognosis of IVCD in structurally normal heart.
Hypothesis: Long-term prognosis of patients with IVCD in structurally normal heart would be poorer than patients without IVCD.
Methods: Between 2000 and 2005, we evaluated the patients who underwent 12-lead electrocardiography. IVCD was defined QRS >110ms without the criteria of complete or incomplete bundle-branch block. The patients were excluded if they had structural heart diseases, such as myocardial infarction, valvular heart disease, congenital heart disease and cardiomyopathy. In a matched-cohort design, 353 patients (IVCD group) (male 83.9% with a mean age of 52.2±13.3 years) were matched for age and sex with 1060 patients (no IVCD group) who had neither IVCD nor structural heart diseases.
Results: During the follow-up of 6.9 ± 3.2 years, the cumulative incidence rates of complete atrioventricular block, heart failure, atrial fibrillation, sick sinus syndrome and all-cause mortality in the IVCD group were higher than no IVCD group (all P < 0.001, except for all-cause mortality (P=0.049)). And using univariate Cox’s regression analysis, only the risk of atrial fibrillation was increased in the IVCD group (hazard ratio(HR) 1.97 [95% confidence interval (CI) 1.26-3.01], p=0.002). However complete atrioventricular block (HR 0.13 [95% CI 0.12-1.53], p=0.10), heart failure (HR 1.69 [95% CI 0.75-3.80], p=0.20), sick sinus syndrome (HR 0.39 [95% CI 0.13-1.46], p=0.16) and all-cause mortality (HR 0.79 [95% CI 0.49-1.73], p=0.79) were not increased in the IVCD group.
Conclusions: In the patients with structurally normal heart, IVCD was associated with future development of atrial fibrillation. However complete atrioventricular block, heart failure, sick sinus syndrome and all-cause mortality were not increased in the patients with IVCD.
Author Disclosures: J. Uhm: None. H. Mun: None. T. Kim: None. H. Lee: None. J. Park: None. J. Park: None. N. Kim: None. B. Joung: None. H. Pak: None. M. Lee: None.
- © 2014 by American Heart Association, Inc.