Abstract 15135: The Cardioprotective Effect of the Modern Farmed Atlantic Salmon -Dietary Spillover from Fish
Introduction: Omega-3 (n-3) long-chain polyunsaturated fatty acids (PUFAs) and in particular DHA and EPA from oily fish have beneficial cardiovascular effects. To meet the demands for sustainability and reduce production cost parts of the marine ingredients in the “modern” Atlantic salmon diet have been replaced by vegetable oil (VO) increasing the monoene fatty acid levels and to some extent the linoleic and linolenic fatty acids on the expense of n-3 PUFAS in the filet. The nutritional as well as cardio protective benefit of the modern farmed Atlantic salmon is therefore under discussion.
Hypothesis: Filets of salmon fed VO with a reduced n-3/n-6 ratio has reduced anti atherosclerotic properties compared to filets of salmon fed FO.
Methods: Fillets of Atlantic salmon fed diets with fish oil (FO) or diets where FO was partly replaced (80%) with rapeseed (RO) or soy oil (SO) were used to prepare western style diets high in fat, sucrose and cholesterol for use in a mouse trial. Three groups of male apoE knock out (KO) mice were fed either of the three western style diets with FO (n=14; alpha-linolenic acid (ALA) level: 1.6 mg/g), SO (n=13; ALA: 2.6 mg/g) or RO (n=13; ALA: 4.0 mg/g) salmon replacing 50% of the dietary protein.
Results: Replacement of FO with SO and RO in the salmon diet led to a significant accumulation of fat in mice livers. Higher red blood cell n-6 levels were detected in SO (1.40 ± 0.18 mg/g) and RO (1.16 ± 0.08 mg/g) fed mice when compared to the FO (0.68 ± 0.05 mg/g) fed groups. Interestingly the HDL cholesterol was higher in RO and SO whereas the LDL cholesterol was high in SO when compared to FO. Despite these metabolic changes, atherosclerotic lesion were reduced in the arch and abdominal region in RO (12 ± 1% and 4 ± 1% respectively) fed mice compared to the FO (18 ± 2% and 10 ± 2% respectively) fed mice.
Conclusions: The dietary spillover from salmon fed VO induced systemic metabolic changes, but also cardio protection in apoE KO mice fed a diet with filets from RO fed salmon. The level of ALA in RO and its potential anti atherosclerotic effect warrants further investigation.
Author Disclosures: A. Bernhard: None. J.D. Rasinger: None. L.K. Midtbø: None. L.S. Myrmel: None. B.E. Torstensen: None. K. Kristiansen: None. L. Madsen: None. T. Brattelid: None.
- © 2014 by American Heart Association, Inc.