Abstract 15077: Bilateral Inflammation in Carotid Arteries in Patients With Coronary Artery Disease is Associated With Increased Rate of Cardiovascular Events
Background: The prognostic role of both local and systemic inflammation in coronary artery disease (CAD) remains controversial. Microwave radiometry (MWR) is a new noninvasive method, which allows the in vivo measurement of the internal temperature of tissues reflecting local inflammation. The aim of the present study was to evaluate in patients with documented CAD the prognostic value of carotid atherosclerotic plaque inflammation, as assessed by MWR, in cardiovascular events.
Methods: Consecutive patients with significant CAD (≥50% stenosis in at least one major epicardial vessel) were prospectively evaluated by 1) carotid ultrasound and 2) microwave radiometry (MWR). Maximum carotid plaque thickness was evaluated in all carotids during the ultrasound study. Temperature difference (ΔT) by MWR was assigned as maximal temperature along the carotid artery minus minimum. ΔT ≥0.90°C was assigned as high ΔT. Major cardiovascular event (MACE) was defined as death, stroke, myocardial infarction or revascularization. All patients were followed-up clinically.
Results: We included 104 consecutive patients with significant CAD. Fifteen patients (14.4%) had high ΔT temperatures bilaterally. The mean follow-up period for all patients was 419±240 days. MACE was 46.7% in the group with bilateral high ΔT and 14.6% in non-high ΔT group (p=0.004). By multivariate logistic regression analysis, ΔT was an independent predictor for MACE, when adjusted for sex, age contemporary risk factors, number of vessels with significant stenosis and maximum carotid plaque thickness (OR: 7.02, 95% CI 1.57-31.36, p=0.01). In Kaplan-Meier plots patients with bilateral high ΔT showed higher event rates, compared with patients in non-high ΔT group (log-rank p=0.001). In specific, patients with bilateral high ΔT showed higher mortality and myocardial infarction rate (log-rank p<0.001 and p=0.03, respectively).
Conclusions: Bilateral inflammation in carotid arteries in patients with coronary artery disease is associated with increased rate of cardiovascular events. Thus, the evaluation of functional characteristics of carotid plaques through Microwave Radiometry may have incremental prognostic impact on risk assessment of CAD patients.
Author Disclosures: G. Benetos: None. K. Toutouzas: None. M. Drakopoulou: None. F. Mitropoulou: None. A. Papanikoloau: None. A. Synetos: None. H. Grassos: None. D. Tousoulis: None. E. Siores: None. C. Stefanadis: None.
- © 2014 by American Heart Association, Inc.