Abstract 15040: Long Term Outcomes After Transcatheter and Surgerical Closure of Atrial Setpal Defect: Implications From National Populational Based Cohort Study in Propensity Score Matching
Introduction: Transcatheter and surgical closure of atrial septal defect were both standard treatment. However, no randomized controlled trial performed compared them directly.
Hypothesis: Surgical closure of atrial septal defect could have worse outcome because surgical wound and anesthesia.
Methods: We enrolled 26,605 patients with atrial septal defect from 2004 to 2011. Inclusion criteria is patient received transcatheter or surgical closure for significant hemodynamic changed atrial septal defect and age is more than 18 years-old. Exclusion criteria were patients with heart failure, pulmonary hypertension, any valve disease and any other congenital heart disease.
Results: There were 510 patients more than 18 year-old have transcatheter and surgical correction, respectively. Compared with two groups, there were higher risk of ischemic stroke (HR=4.72, P=0.006), systemic thromboembolism (HR=5.31, P=0.003), atrial fibrillation (HR=1.69, P=0.048), heart failure (HR=2.30, P<0.001), and all-cause mortality (HR=4.04, P<0.001) for patients in surgical closure group. All favorable outcomes occurred in intervention admission and follow-up period.
Conclusions: Patients received transcatheter intervention for significant hemodynamic changed atrial septal defect have favorable outcomes than surgical closure.
Author Disclosures: T. Chen: None. Y. Hsiao: None. C. Cheng: None.
- © 2014 by American Heart Association, Inc.