Abstract 14978: Higher Serum Uric Acid is Associated with Arterial Stiffening and Cardiac Hypertrophy in Childhood Obesity
Background: Hyperuricemia has been implicated in the mechanism of cardiovascular dysfunction in adulthood obesity. However, few studies have examined uric acid and cardiovascular function in overweight/obese children. The purpose of this study is to assess the relationship between uric acid and cardiovascular function in children.
Methods: Echocardiography was performed in 235 children aged 6 to 15 years. Left ventricular (LV) end-diastolic volume and LV mass were measured and LV mass-to-volume ratio was calculated. Stroke volume (SV) was measured using aortic diameter and pulsed Doppler velocity profile. SV was indexed for body surface area (SVI). Total arterial compliance (Ca) was estimated by the ratio of pulse pressure/SVI. Quantitative B-mode ultrasound scans were used to measure intima-media thickness (IMT) and diameters of the common carotid artery, and carotid stiffness (ß) was calculated. High sensitive C-reactive protein (hs-CRP), uric acid, lipids, insulin, and homeostasis model assessment for insulin resistance (HOMA-IR) were also assessed.
Results: There were significant relationships between BMI and uric acid, triglycerides, high-density lipoprotein cholesterol (HDL-C), insulin, HOMA-IR, and hs-CRP (r = 0.45, 0.39, -0.31, 0.51, 0.54, and 0.28, p < 0.01, respectively). Systolic blood pressure, mass-to-volume ratio, Ca, ß index, and IMT increased significantly with BMI (r = 0.41, 0.45, 0.34, .28, and 0.37, p < 0.01, respectively. There were significant relationships between Ca and uric acid and triglycerides (0.25 and 0.21, p < 0.01, respectively), between ß index and uric acid and HOMA-IR (0.17, p < 0.05 and 0.21, p < 0.01, respectively), and between mass-to-volume ratio and uric acid, HOMA-IR, and HDL-C (0.29, 0.28, and -0.24, p < 0.01, respectively). In multivariate analysis, uric acid was independent determinants of systolic blood pressure, Ca, ß index, and mas-to-volume ratio. No significant relationships were observed between hs-CRP and Ca, IMT, and ß index.
Conclusions: Obesity-related hyperuricemia associated with vascular functional changes may contribute to the increased prevalence of later cardiovascular diseases.
Author Disclosures: K. Harada: None. Y. Harada: None.
- © 2014 by American Heart Association, Inc.