Abstract 14879: High dose Vitamin D Supplementation Attenuates Left Atrial Enlargement in African American Men with Hypovitaminosis D and Dysglycemia: Results of the D-Vitamin Intervention in Veteran Administration (DIVA) Randomized Controlled Trial
Introduction: Vitamin D deficiency is common among African American men (AAM) in the United States and is associated with increased cardiovascular disease risk. This study evaluated the effect of high-dose vitamin D supplementation on echocardiographic parameters in AAM with dysglycemia and hypovitaminosis D.
Hypothesis: High dose vitamin D therapy will improve structural and diastolic echocardiographic parameters.
Methods: AAM with dysglycemia (A1C 5.7-6.9% and no hypoglycemic drugs) and low vitamin D levels (25OHD: 5.0-29ng/ml) were randomized to high-dose ergocalciferol (50,000 IU/week) or placebo. Echocardiography was performed at baseline and at 1 year. Ejection fraction (EF), septal and posterior wall thickness, left ventricular end diastolic diameter (LVEDd), left ventricular end systolic diameter (LVEDs), left atrial (LA) area, LA length, LA volume, E, A, septal and lateral e’ and a’, deceleration time (DT), and isovolumetric relaxation time (IVRT) were measured.
Results: 81/158 (51%) patients received ergocalciferol. Baseline characteristics were similar between groups (Table 1). LA area and LA volume significantly increased in the placebo arm but not in the therapy arm (Table 2). There was no significant change in most other structural or diastolic parameters between groups.
Conclusions: The results suggest that vitamin D may prevent left atrial remodeling in AAM with dysglycemia and hypovitaminosis D independent of its effect on diastology or chamber size and thickness.
Author Disclosures: S. Pauwaa: None. I. Ciubotaru: None. M. Kansal: None. E. Barengolts: None.
- © 2014 by American Heart Association, Inc.