Abstract 14798: Right Atrial Function as Prognostic factor in Patients with Pulmonary Hypertension
Background: The development of right ventricular (RV) dysfunction in patients with pulmonary hypertension (PH) has been associated with adverse outcomes. Right atrial (RA) function could be a prognostic factors as well as RV function, but non-invasive evaluation of RA function is limited. Our objective was thus to test the hypothesis that RA function was associated with hemodynamic parameters of RV performance in PH patients.
Methods: Eighty PH patients with mean pulmonary artery pressure (PAP) of 40±11mmHg (all≥25mmHg) were recruited in this study. RA function was assessed by using two-dimensional speckle-tracking strain from RV-focused apical 4-chamber view. RA strain was calculated with the reference point set at the P wave, which enabled the recognition of peak negative (RAneg), positive strain (RAposi), and the sum of those values (RAtotal), corresponding to RA contractile, conduit, and reservoir function, respectively. All patients underwent right-heart catheterization for measurement of mean PAP and pulmonary vascular resistance (PVR).
Results: RAneg (r=0.24 and p=0.03), RAposi (r=0.31 and p=0.01) and RAtotal (r=0.35 and p=0.001) were significantly correlated with mean PAP. In addition, RAposi (r=0.41 and p<0.001) and RAtotal (r=0.44 and p<0.001) were also correlated with PVR.
Conclusions: Non-invasively assessed RA strains were associated with mean PAP and PVR. RA strain may be of a valuable additive factor for the management of PH patients, and thus have potential clinical applications.
Author Disclosures: Y. Fukuda: None. H. Tanaka: None. Y. Motoji: None. K. Ryo: None. H. Matsuzoe: None. K. Hatazawa: None. Y. Hatani: None. K. Dokuni: None. H. Toki: None. H. Shimoura: None. J. Ooka: None. H. Sano: None. T. Sawa: None. Y. Mochizuki: None. K. Tatsumi: None. K. Matsumoto: None. N. Emoto: None. K. Hirata: None.
- © 2014 by American Heart Association, Inc.