Abstract 14763: Acute Effects of Exercise on Arterial Stiffness in Patients with Heart Failure with Preserved Ejection Fraction; The Role of Inflammatory Status
Aortic stiffening and endothelial dysfunction have been shown to be associated with heart failure with preserved EF (HFPEF). These were assessed at rest and after exercise in patients with HFPEF.
The study consisted of 18 patients with HFPEF, of 43 hypertensive patients without heart failure and of 29 age-matched control subjects. Cardio ankle vascular index (CAVI) and C-reactive protein (CRP) were used as indexes of arterial stiffness and inflammation, respectively
Results: CAVI was significantly greater in hypertensive (HT) patients and in HFPEF patients than in control subjects at rest (9.1 ± 1.0, 9.3 ± 1.1 vs. 8.5 ± 1.1, p<0.05, p<0.05, respectively). CAVI decreased after exercise in control subjects and in HT patients, but even increased in HFPEF patients (p<0.01 vs control subjects; p<0.01 vs HT). The levels of CRP were significantly higher in the HFPEF patients than in the control subjects (p<0.05) and in HT patients (p<0.05). The exercise-induced change in CAVI was larger in those with higher level of CRP at rest (p<0.05).
Conclusions: Aortic stiffness at rest and after exercise was increased in HFPEF and that was associated with inflammatory status. Not only aortic stiffening but inflammation appears to contribute to the exercise intolerance in patients with HFPEF.
Author Disclosures: M. Masaki: None. T. Mano: None. S. Hirotani: None. A. Eguchi: None. S. Fujiwara: None. M. Sugahara: None. M. Koshiba: None. T. Masuyama: None.
- © 2014 by American Heart Association, Inc.