Abstract 14724: Cardiometabolic Benefits of Exercise Training Among Fitness Non-responsive Patients with Type 2 Diabetes Mellitus: HART-D Study
Introduction: Exercise training is associated with improved cardiorespiratory fitness (CRF) and metabolic profiles among patients with type 2 diabetes mellitus (T2DM). However, there is substantial heterogeneity in the magnitude of CRF response to exercise training, and it is uncertain if the metabolic effects of exercise training are limited to those patients who improve their CRF.
Methods: The analysis sample included participants from the Health Bene[[Unable to Display Character: ﬁ]]ts of Aerobic and Resistance Training in Individuals with Type 2 Diabetes (HART-D) trial who were randomized to a control group or one of the 3 supervised exercise training groups (aerobic, resistance or combined) for 9 months. CRF response was defined as change in measured peak absolute oxygen consumption ([[Unable to Display Character: ∆]]VO2-peak, L O2/min) from baseline to end of study, using an exercise treadmill protocol. Participants were classified based on [[Unable to Display Character: ∆]]VO2-peak into exercise responders (E-R; [[Unable to Display Character: ∆]]VO2-peak> 0) and non-responders (E-NR; [[Unable to Display Character: ∆]]VO2-peak < 0). Changes in metabolic profiles with exercise training were compared across control, E-R and E-NR groups.
Results: A total of 211 participants (mean age: 57; 62 % women) were included in the study, with among the exercise groups (n=174), there was substantial heterogeneity in [[Unable to Display Character: ∆]]VO2-peak; only 56% had CRF improvement with exercise training (E-R: 97; E-NR: 77). Compared with controls, E-NR group had significant improvement in glycosylated hemoglobin (A1C) and other metabolic measures (Table). While the E-R group had a significantly greater increase in VO2-peak as compared with E-NR, there were no significant differences in the magnitude of improvement in A1C and other metabolic parameters between the two groups (Table).
Conclusion: Exercise training in patients with T2DM is associated with a significant improvement in glucose control and other metabolic parameters independent of improvement in cardiorespiratory fitness.
Author Disclosures: A. Pandey: None. D. Swift: None. D. McGuire: None. C. Ayers: None. I. Neeland: None. N.M. Johannsen: None. S.N. Blair: None. C.P. Earnest: None. T. Church: None. J. Berry: None.
- © 2014 by American Heart Association, Inc.