Abstract 14676: Determinants of Cardiac Troponin Levels in Healthy Adults
Introduction: Modern high-sensitive cardiac troponin (cTnI) assays enable detection of cTnI levels and quantification of subclinical myocardial injury in the general population. However, little is known about factors that determine cTnI levels in the community.
Hypothesis: We aimed to assess the determinants of cTn levels among young and healthy individuals.
Methods: Our population-based study included 1568 well-characterized adults aged 25-41 years without overt cardiovascular disease and diabetes. cTnI was measured using a high-sensitive assay (limit of detection 0.04 ng/L). Backward linear regression analyses including a broad set of covariates were performed to identify variables independently associated with cTnI levels.
Results: Median age of our population was 38 years, 735 (46.9%) were male. cTnI was quantifiable in all but 5 participants (99.7%), the median cTnI level being 0.68 (interquartile range 0.43; 1.20) ng/L. Median (interquartile range) cTnI was significantly higher in men than in women (1.01 (0.70; 1.71) versus 0.47 (0.33; 0.70) ng/L, p<0.0001). A large number of covariates was significantly associated with cTnI in multivariable models, as shown in the Table. The strongest relationships were observed with male gender, systolic blood pressure, heart rate, left ventricular mass, creatinkinase and aspartate-aminotransferase (all p<0.0001). The R-Square of the final model was 0.37, suggesting that this model explained 37% of the overall cTnI variability in the population.
Conclusions: Men have substantially higher cTnI levels than women, even after multivariable adjustment. In addition, cTnI levels in the general population are associated with many covariates representing a large number of pathogenic mechanisms. These factors should be taken into account when the clinical utility of cTn is evaluated.
Author Disclosures: M. Bossard: None. S. Aeschbacher: None. T. Schoen: None. J. Estis: Employment; Significant; Singulex, Inc. J. Todd: Employment; Significant; Singulex, Inc.. M. Risch: None. C. Mueller: None. L. Risch: None. D. Conen: None.
- © 2014 by American Heart Association, Inc.