Abstract 140: Hemodynamic Efficacy and Gas Exchange During Continuous Chest Compressions or 30:2 Compression-to-Ventilation Ratio During Mechanical CPR in a Porcine Model of Cardiac Arrest
Introduction: A compression-ventilation (C:V) ratio of 30:2 is recommended for adult cardiopulmonary resuscitation (CPR). Continuous chest compression (CCC) minimizes interruption of chest compression especially when the airway is protected. In the present study, we investigated the effects of 30:2 and CCC with fixed ventilation on hemodynamic efficacy and gas exchange in a porcine model.
Hypothesis: Hemodynamic efficacy achieved in CCC is better than those in 30:2 mechanical CPR without a negative effect to the gas exchange.
Methods: Ten male domestic pigs weighing 38±2 kg were utilized. Ventricular fibrillation was electrically induced and untreated for 7 mins. The animals were then randomized to receive CCC with fixed ventilation (CCC group) or 30:2 CPR (VC group). Coincident with the start of compression, the animals were mechanically ventilated at a rate of 10 breaths-per-minute in the CCC group or with a C:V ratio of 30:2 in the VC group. Defibrillation was attempted by a single 150 J shock. If resuscitation was not successful, CPR was resumed for 2 mins prior to the next defibrillation until either successful resuscitation or for a total of 15 mins.
Results: All animals were successfully resuscitated. Coronary perfusion pressure and carotid blood flow generated during CPR in the VC group were no different to those achieved in the CCC group (Table 1). No significant differences were observed in arterial blood gases between both groups at 1 and 30 mins post-resuscitation (Table 2).
Conclusion: Similar hemodynamic efficacy and gas exchange were observed between continuous compression with fixed ventilations and 30:2 compressions-to-ventilations ratio during mechanical CPR.
Author Disclosures: Z. Yang: None. P. Gong: None. X. Wu: None. J. Qian: None. N. Duggal: None. W. Tang: None.
- © 2014 by American Heart Association, Inc.