Abstract 13935: Effect of Dietary Salt Restriction on Blood Pressure in Chinese Adults: A Meta-Analysis
Introduction: Controlling elevated blood pressure by reducing dietary salt intake might reduce cardiovascular disease. The effects of salt restriction on blood pressure and a culturally-tailored salt reduction strategy (potassium-for-sodium salt substitution) have not been summarized in Chinese adults.
Methods: PubMed and China National Knowledge Infrastructure databases were searched for studies satisfying search criteria. Outcomes extracted from each study were 24-hour urinary sodium excretion, NaCl intake, and SBP before and after dietary salt lowering. A random-effects meta-analysis was performed using Stata software and results were evaluated for publication bias and excess heterogeneity. Most studies aggregated results for hypertensive and normotensive participants. We therefore stratified pooled meta-analysis results into two groups: hypertensive participants only and a mixture of hypertensive and normotensive participants. Salt substitution studies did not report SBP change separately for hypertensive and normotensive participants.
Results: Data were pooled for five studies, representing 2,458 Chinese participants. In hypertensive participants, the pooled estimate of change in 24-hour urinary Na excretion was -163.0 (95% CI: -233.5 to -92.5) mmol/day, which was associated with a reduction of -8.9 (95%CI: -14.1 to -3.7) mmHg in SBP and -5.9 (95%CI: -9.7 to -2.1) mmHg DBP. Each 1g dietary NaCl reduction was associated with reductions of 0.94 mmHg SBP (95%CI: 0.69 to 1.03). These SBP effects in the hypertensive group were 1.96 times more compared with the mixed hypertensive and normotensive group. Salt substitution was associated with a -2.3 (95%CI: -5.6 to 0.9) mmHg change in SBP level.
Conclusions: The Chinese population might gain improved blood pressure control from salt restriction and hypertensives would benefit the most. The effect of salt substitution intervention on blood pressure in hypertensive patients should be examined.
Author Disclosures: M. Wang: None. A. Moran: None. J. Liu: None. Y. Qi: None. W. Xie: None. K. Tzong: None. D. Zhao: None.
- © 2014 by American Heart Association, Inc.