Abstract 13926: Testosterone Drop Predicts Glucose Rise in Men on Statins
Background: Data from the UCSD Statin Study previously showed that statins significantly reduce testosterone in men, with magnitude of drop related to LDL-drop on simvastatin and to HDL-rise on pravastatin. Since lower testosterone is linked to greater diabetes risk in men: we conjectured that testosterone drop on statins might contribute to instances of glucose rise on statins.
Methods: 1016 participants in the UCSD Statin Study underwent sex-stratified randomization equally to simvastatin 20mg, pravastatin 40mg or placebo for 6 months; 692 were men (age 20-85). Fasting glucose (mg/dL) and testosterone (ng/mL) were assessed at baseline and 6 months. Regression analysis with robust standard errors evaluated the relation of change in testosterone to change in glucose in men, adjusted for baseline testosterone and baseline glucose. Analyses were stratified by randomization assignment and age (≥55, N=353 vs age<55, N= 341).
Results: Change in testosterone predicted change in glucose on statins [[Unable to Display Character: –]] and also on placebo (consistent with previously known relationships of testosterone to glucose in men). The magnitude of association was apparently larger on statins, particularly simvastatin, than on placebo in older age (≥ 55).
Discussion: Statin induced reductions in testosterone, coupled with association of testosterone drop to glucose rise, may contribute to instances of glucose elevation in men on statins.
Author Disclosures: B.A. Golomb: None. A.K. Bui: None.
- © 2014 by American Heart Association, Inc.