Abstract 13777: Relationship of Office and Ambulatory Blood Pressure with Left Ventricular Global Longitudinal Strain
Introduction: High blood pressure (BP) is a strong risk factor for heart failure. Ambulatory BP (ABP) is a better predictor of cardiovascular events, including heart failure, than office BP. Left ventricular (LV) global longitudinal strain (GLS) can detect early subclinical cardiac dysfunction even when LV ejection fraction (EF) is normal. We investigated the relationship of ABP with GLS in a community-based cohort with normal LVEF.
Methods: Two-dimensional speckle tracking echocardiography and 24-hour ABP monitoring were performed in 577 participants (mean age 70 ± 9 years; 60% women) with normal LVEF (≥50%) from the Cardiovascular Abnormalities and Brain Lesions (CABL) study.
Results: Higher BP values, both ABP and office BP, were consistently associated with lower (i.e., less negative) GLS. After adjustment for pertinent covariates (age, sex, race/ethnicity, body mass index, diabetes mellitus, coronary artery disease, LV mass index, and antihypertensive medication), office diastolic BP [B (SE)=0.04 (0.01), p=0.003] and 24-hour systolic and diastolic ABP [B (SE)=0.04 (0.01), p<0.0001; and B (SE)=0.08 (0.02), p<0.0001, respectively] were independently associated with GLS. When ABP and office BP were included in the same model, only ABP remained significantly associated with GLS (table).
Conclusions: Higher ABP values are strongly associated with lower GLS in subjects with normal LVEF, independent of cardiovascular risk factors and office BP. ABP monitoring may be of value for the early identification of subjects at increased risk of developing heart failure.
Author Disclosures: F. Sera: None. Z. Jin: None. C. Russo: None. E.S. Lee: None. J.E. Schwartz: None. T. Rundek: None. M.S. Elkind: None. S. Homma: None. R.L. Sacco: Consultant/Advisory Board; Modest; Boehringer Ingelheim Consultant on the design of a secondary stroke prevention trial with Dabigatran. M.R. Di Tullio: None.
- © 2014 by American Heart Association, Inc.