Abstract 13775: Clinical Significance of Flow Energy Loss inside the Left Ventricle via Cardiovascular Magnetic Resonance in Non-ischemic Dilated Cardiomyopathy
Background: Blood flow patterns are closely linked to the morphology and function of the cardiovascular system and its efficiency can be estimated with flow energy loss (FEL). We have made it passible to measure FEL by using 2D cine phase-contrast (PC) cardiac magnetic resonance (CMR) technique. The object of the present study is to reveal the relationship of the clinical parameter and FEL in patients with non-ischemic dilated cardiomyopathy (DCM).
Methods: A cross-sectional study was carried out on patients with DCM. All patients underwent CMR technique including late gadolinium enhancement (LGE). Intramural geometry was extracted with Steady-state free precession series, and PC-CMR was superposed. Blood flow was visualized and FEL with viscous dissipation was calculated in-house code.
Results: A total of nineteen such patients were included in this study. FEL inside the left ventricle (LV) was 331 ± 117 mW/m2 (range 188-626). FEL was significantly correlated with age (r = -0.53, P = 0.02) and LV end-diastolic volume (LVEDV) (r = 0.50, P = 0.03), but not with LV ejection fraction (r = -0.08, P = 0.75) or plasma blood natriuretic peptide level (r = 0.05, P = 0.85). Especially, FEL tended to be correlated with LVEDV (r = 0.69, P = 0.06) in LGE positive patients, but did not in LGE negative. Well organized vortex flow dissipated small FEL, whereas disturbed flow inside highly-dilated LV dissipated large FEL (figure A, B).
Conclusions: FEL was significantly correlated with age and LVEDV in DCM patients. Large LV caused disturbed flow resulting in high FEL. FEL was considered to be more sensitive parameter in damaged LV tissue than in non-damaged.
Author Disclosures: T. Nabeta: None. K. Itatani: None. Y. Iida: None. Y. Ikeda: None. S. Ishii: None. T. Naruke: None. H. Shinagawa: None. T. Inomata: None. K. Miyazi: None. J. Ako: None.
- © 2014 by American Heart Association, Inc.