Abstract 13714: Association between Intensively Controlled Low-density Lipoprotein Cholesterol and Clinical Outcomes in Patients with Peripheral Artery Disease after Angioplasty
Objective: The purpose of this study was to evaluate the association between intensively controlled low-density lipoprotein (LDL) cholesterol and clinical outcomes in patients with peripheral artery disease (PAD).
Background: Although statin medication is recommend for reducing atherosclerotic cardiovascular events, the achieved LDL cholesterol levels are diverse. There are little data about the relation between achieved LDL cholesterol levels and clinical outcomes in PAD patients.
Methods: The study population consisted of 242 patients with PAD who underwent percutaneous transluminal angioplasty (PTA) from 2011 through 2012. We categorized the patients according to the achieved LDL cholesterol level at 4 months after PTA [well-controlled LDL group (LDL level≤70mg/dL, n=114) and uncontrolled LDL group (LDL level>70mg/dL, n=128)]. The primary endpoint was major adverse cardiovascular and cerebrovascular events (MACCE) defined as a composite of cardiac death, myocardial infarction, stroke, target lesion revascularization, and unplanned amputation.
Results: Baseline characteristics including age, sex, BMI, history of hypertension, diabetes, strokes, previous vascular disease and pre-procedural lipid profiles are similar between each group. There was significant difference in achieved LDL cholesterol level between the two groups (55.7±10.6 vs. 92.9±20.6mg/dl, p <0.001). Patients were followed for 20.0 (10.8-25.0) months. MACCE occurred less frequently in patients with well-controlled LDL (27.2% vs. 41.4%, p=0.027). A multivariate Cox regression analysis showed that intensive LDL cholesterol control (LDL level≤70mg/dL) was an independent predictive factor for MACCE (HR= 0.572, 95% CI=0.365-0.896, p=0.015).
Conclusions: Intensively controlled LDL cholesterol level significantly reduced MACCE in patients with PAD after PTA.
Author Disclosures: J. Lee: None. D. Shin: None. J. Kim: None. B. Kim: None. M. Hong: None. Y. Jang: None. D. Choi: None. Y. Ko: None.
- © 2014 by American Heart Association, Inc.