Abstract 13684: Subclinical Atherosclerosis in Diabetic Patients with Low to Intermediate Risk: Coronary Computed Tomographic Angiographic Findings from Matched Asymptomatic Individuals with and without Diabetes
Objectives: The purpose of this study was to investigate the effect of subclinical atherosclerosis in asymptomatic individuals with low to intermediate risk according to the presence or absence of diabetes mellitus.
Background: There is limited data regarding the impact of diabetes mellitus on the risk of subclinical atherosclerosis in asymptomatic individuals with low to intermediate risk.
Methods: We analyzed 1,688 propensity-score matched individuals with low to intermediate risk who underwent coronary CT angiography (Figure 1). Coronary artery calcium score (CACS), atherosclerotic plaque, degree of coronary artery disease (CAD), and clinical outcomes were assessed. High-risk CAD was defined as at least two-vessel disease with proximal left anterior descending artery(LAD) involvement, three-vessel disease, and left main disease.
Results: The mean age of matched individuals was 54.9±7.6 years, and 1,392 (82.5%) were male. Diabetic individuals had higher CACS (76.7±205.3 versus 54.4±171.6, p=0.013), more atherosclerotic plaque (54.5% versus 49.2%, p=0.030), more significant CAD (≥50% diameter stenosis, 13.4% versus 6.8%, p<0.001), more proximal LAD involvement (4.6% versus 2.4%, p=0.017), and more high-risk CAD (4.0% versus 2.0%, p=0.022) than non-diabetic individuals. However, during the follow-up period (median 21.8 months), there was no significant difference in the composite outcome of all-cause death, MI, and coronary revascularization (hazard ratio=1.627, 95% confidence interval=0.904-2.930, p=0.105).
Conclusions: In asymptomatic individuals with low to intermediate risk, matched diabetic individuals had more subclinical atherosclerosis, but there was no difference in clinical events between matched diabetic and non-diabetic individuals.
Author Disclosures: Y. Cho: None. Y. Kim: None. S. Lee: None. G. Park: None. S. Her: None. D. Kim: None.
- © 2014 by American Heart Association, Inc.