Abstract 13674: Propagation Velocity of Early Diastolic Filling Flow is a Superior Parameter for Assessing Exercise Tolerance
Introduction: Propagation velocity of left ventricular (LV) early diastolic filling flow (Vp) is not only a parameter of LV isovolumic relaxation as known but also a parameter of LV early diastolic filling itself. LV elastic recoil derived from good LV systolic function is recognized to strongly affect this index. We assessed whether Vp is superior to other Doppler echocardiographic parameters for predicting exercise capacity.
Methods: Ninety-two consecutive patients with preserved LV ejection fraction (EF) who underwent both Doppler echocardiography at rest and cardio-pulmonary exercise testing (CPX) were enrolled. We measured EF, peak early diastolic transmitral flow velocity (E), peak late diastolic transmitral flow velocity (A), e’, and Vp by Doppler echocardiography. After the echocardiographic examinations, symptom-limited exercise test was performed with simultaneous respiratory gas analysis, and peak oxygen consumption (pVO2) was determined.
Results: Significant positive correlations were observed between Vp, as well as e’ and pVO2 (r=0.59 and r=0.54, respectively, p<0.0001). In contrast, the correlation coefficients of E/Vp and E/e’ with pVO2 did not exceed those of Vp and e’ with pVO2 (r=-0.38, p=0.0002 and r=-0.46, p<0.0001, respectively). Age, EF, and E/A were also weakly correlated with pVO2 (r=-0.37, p=0.0003; r=0.29, p=0.005; r=0.44, p<0.0001, respectively). In the multivariate regression analysis, Vp (β=0.44, p<0.0001) and e’ (β=0.29, p=0.002) were selected as significant determinants for pVO2 (r=0.64, p<0.0001).
Conclusions: Vp had a best correlation with exercise tolerance in patients with preserved LV systolic function.
Author Disclosures: S. Kikuchi: None. I. Noriyuki: None. T. Goto: None. K. Wakami: None. O. Nobuyuki: None.
- © 2014 by American Heart Association, Inc.