Abstract 13609: Prognostic Impact of Pulmonary Vascular Resistances Estimated by Cardiac Magnetic Resonance in Chronic Heart Failure With Reduced Ejection Fraction
Introduction: Pulmonary hypertension is an indicator of worse prognosis in chronic heart failure (HF). As reported in recent years, pulmonary vascular resistances (PVR) could be accurately estimated by cardiac magnetic resonance (CMR).
Hypothesis: We sought to assess the prognostic utility of noninvasive calculation of PVR in patients with systolic HF.
Methods: Prospective registry of patients with left ventricular ejection fraction (LVEF) <40% and admitted for acute decompensated HF from July 2011 to April 2014. Readmission for HF and all-cause mortality were considered as primary endpoint at follow-up.
Results: 105 patients (65.7 years, LVEF 26.0%, ischemic 46%) were included. Patients with primary event had higher PVR: 6.93±1.9 vs. 4.67±1.7 Wu [Wood units] (p<0.001). In multivariate Cox regression analysis, PVR ≥5.2 Wu (cutoff point according ROC curve) was independently associated with increased risk of primary event at 10 months follow-up (HR 4.1 [95% CI 1.5-11.2], p=0.007)(see Table). Kaplan-Meier curve shows event-free survival in both groups according PVR (see Figure; time in days).
Conclusions: Noninvasive estimation of PVR by CMR might be useful in risk stratification of patients with systolic HF, irrespective of etiology, right ventricular ejection fraction or presence of LGE.
Author Disclosures: Ó. Fabregat-Andrés: None. J. Estornell-Erill: None. F. Ridocci-Soriano: None. A. Cubillos-Arango: None. B. Bochard-Villanueva: None. P. García-González: None. L. Facila: None. R. Payá-Serrano: None. S. Morell: None. J. Cortijo: None.
- © 2014 by American Heart Association, Inc.