Abstract 13600: The Effect of Statins on Aortic Root Dimensions in Bicuspid Aortic Valve Disease
Introduction: In bicuspid aortic valve (BAV) disease, the growth rate of the aortic root is higher compared to tricuspid aortic valves. Statins decrease the growth rate of abdominal aneurysms; however their effect on the growth rate of the aortic root has not been elucidated. The present study evaluated the effect of statins on the increase in aortic root dimensions in BAV patients.
Methods: A total of 178 patients (42 ± 15 years, 69% male) with BAV who underwent ≥ 2 echocardiographic measurements of the aortic root ≥ 1 year apart were included in the present retrospective evaluation. Patients with connective tissue disease, aortic coarctation, subvalvular membrane or ascending aorta diameter of ≥ 45 mm at baseline were excluded. Median follow up duration was 4.6 years (interquartile range: 2.5-7.9 years). Growth rate (mm/year) was determined by instrumental variables estimation using linear regression analysis.
Results: Patients treated with statins (n=36) were significantly older and had more cardiovascular risk factors than their counterparts (n=142). The aortic diameters were significantly smaller at baseline and at follow up in statin users compared to non-users when adjusted for age and follow up duration (Figure 1). The average annual growth rate was 0.08 mm/year (95% confidence interval: 0.03-0.13) for the aortoventricular junction, 0.18 mm/year (0.13-0.22) for the sinus of Valsalva, 0.17 mm/year (0.12-0.22) for the sinotubular junction and 0.45 mm/year (0.38-0.53) for the ascending aorta. The annual growth rate of the aortic segments was not different between statin users and non-users.
Conclusions: In patients with BAV, the use of statins is associated with smaller aortic root diameters. However, the annual growth rate of the aortic root is not influenced by the use of statins.
Author Disclosures: M.V. Regeer: None. P.J. van Rosendael: None. V. Kamperidis: Research Grant; Modest; European Society of Cardiology training grant, Hellenic Society of Cardiology training grant. J.J. Bax: None. N. Ajmone Marsan: None. V. Delgado: Consultant/Advisory Board; Modest; Medtronic, St. Jude Medical.
- © 2014 by American Heart Association, Inc.