Abstract 13521: Augmented Inflammation in Pericoronary Adipose Tissue in Patients with Advanced Coronary Artery Disease
Introduction: Epicardial adipose tissue (EAT), a visceral adipose tissue surrounding the heart, is associated with coronary atherosclerosis. However, the spatial distribution of inflammation within EAT has not been investigated. Multidetector computed tomography (MDCT) is useful for the assessment of tissue characteristics in vivo. This study aimed to investigate the inflammatory status of pericoronary EAT and its association with the radiodensity of contrast-enhanced MDCT in patients with coronary artery disease (CAD).
Methods: Fifteen patients who underwent contrast-enhanced MDCT examination before elective coronary artery bypass grafting (CABG) were recruited. Four fat samples were obtained at surgery including pericoronary EAT, non-pericoronary EAT, extrapericardial fat, and subcutaneous fat (Figure left). MDCT assessment included CT radiodensity at 4 sites of fat depots. Five patients who underwent valvular surgery without CAD were also enrolled.
Results: In 15 patients who underwent CABG, monocyte chemotactic protein-1, interleukin (IL)-1β, IL-6, and tumor necrosis factor-α levels were higher in pericoronary EAT than in other fat depots (all p<0.05) (Figure right). The values of these inflammatory mediators were related to MDCT radiodensity (all p<0.01). In 5 patients without CAD who underwent valvular surgery, levels of inflammatory mediators were similar among pericoronary EAT and the other 3 fat depots.
Conclusion: This study demonstrated significantly augmented inflammation in pericoronary EAT in patients with advanced CAD, which was associated with contrast-enhanced MDCT radiodensity.
Author Disclosures: K. Nakanishi: None. S. Fukuda: None. A. Tanaka: None. T. Ikuta: None. K. Otsuka: None. K. Matsumoto: None. J. Yoshikawa: None. K. Shimada: None. M. Yoshiyama: None.
- © 2014 by American Heart Association, Inc.