Abstract 13516: Impact of Carotid Artery Pulsatility on Left Ventricular Diastolic Function in Patients With Subclinical Coronary Risk Factors
Background: Ventricular-arterial interaction is an important pathophysiology of heart failure with preserved ejection fraction. Carotid artery (CA) intima-media thickness (IMT) and pulsatility can be used as an index of pan-arterial stiffening. In this study we sought to evaluate relationship between CA characteristics and left ventricular (LV) diastolic function in patients with subclinical coronary risk factors.
Methods: We retrospectively analyzed consecutive images of 3,511 primary patients who underwent both carotid ultrasound and echocardiography within a month. After exclusion of overt coronary artery disease, valvular heart diseases, cardiomyopathies, congenital heart diseases and LV ejection fraction less than 50%, we analyzed their relationship in 946 patients. Carotid plaque characterization, IMT, peak systolic velocity (PSV) and end-diastolic velocity (EDV) and resistive index (RI) were measured in common, external and internal carotid arteries. As an index of LV diastolic function, E/e’ was used.
Results: Their mean age was 60.2±12.3 years and 404 (43%) were women. Five hundred fifty-three (59%) had hypertension and 209 (22%) had diabetes. E/e’ was correlated with age, sex, LV mass index, carotid IMT, presence of plaque, common CA-EDV, -RI and internal CA-RI. In multivariable analysis, common-EDV and RI were independently correlated with E/e’ after controlling for significant parameters in univariate analysis but not with IMT and presence of plaque.
Conclusion: Carotid EDV and RI rather than IMT were independently related to diastolic function in patients with preserved ejection fraction and subclinical risk factors. Therefore carotid-EDV and RI can be used as an index of atherosclerosis and LV diastolic function.
Author Disclosures: K. Kim: None. J. Cha: None. H. Chung: None. J. Kim: None. Y. Yoon: None. B. Lee: None. B. Hong: None. S. Rim: None. H. Kwon: None. E. Choi: None.
- © 2014 by American Heart Association, Inc.