Abstract 13494: Environmental Tobacco Smoke Exposure is Associated with Dyslipidemia and Left Ventricular Structural and Functional Changes in Children
Background: Environmental tobacco smoke (ETS) exposure is one of the most important preventable risk factors for cardiovascular events, however, its effects on cardiovascular function are not well characterized in children. To clarify this, we examined lipids and left ventricular (LV) geometry and function in ETS children.
Methods: Echocardiography with tissue Doppler imaging was performed in102 children (age:10±3 years) who have been exposed to tobacco smoking since intrauterine life and 128 age-matched children without ETS. Left atrial anteroposterior diameter, LV end-diastolic volume, ejection fraction (EF), mass,mass-to-volume ratio, and carotid artery intima media-thickness (IMT) were measured. Transmitral peak flow velocities during early and late diastole and mitral annular myocardial velocities during early (Em) and late diastole (Am) were measured. Left atrial systolic force was calculated. Isovolumic relaxation time (IRT) and tissue Doppler-derived myocardial performance index (MPI) were assessed. High sensitive C-reactive protein (hs-CRP), lipids, insulin, and homeostasis model assessment for insulin resistance (HOMA-IR) were also assessed.
Results: Body mass index and heart rate were similar between the 2 groups (p>0.05). Systolic and diastolic pressures and triglycerides were significantly higher in ETS children than in controls (112±10 vs. 109±9 mmHg, 64±8 vs. 61±8 mmHg, and 102±65 vs.78±40 mg/dl, p < 0.05, respectively). High-density lipoprotein cholesterol, HOMA-IR, and hs-CRP did not differ between the 2 groups. Compared with controls, left atrial size, LV mass, mass-to-volume ratio, and left atrial systolic force were significantly higher (2.6±0.40 vs. 2.4±0.31 cm, 90±46 vs. 79±31 g, 1.08±0.22 vs. 1.01±0.20, and 3.96±2.03 vs. 3.36±1.69 kdyne, p < 0.05, respectively) and Em/Am ratio was significantly lower (2.96±0.67 vs. 3.14±0.77, p < 0.05) in ETS children. EF, IRT, MPI, and carotid IMT did not differ between the 2 groups.
Conclusions: Tobacco smoke exposure can adversely affect serum lipids and cardiac geometry and function in childhood. Passive smoking may contribute to the increased prevalence of later cardiovascular diseases.
Author Disclosures: K. Harada: None. Y. Harada: None.
- © 2014 by American Heart Association, Inc.