Abstract 13482: Urinary Concentrations of Isoflavones Are Not Associated With Risk of Incident Coronary Heart Disease: The Singapore Chinese Health Study
Introduction: Data from prospective studies examining dietary intakes of soy isoflavones in relation to coronary heart disease (CHD) risk have been inconsistent, which may be partially due to the limitations in using questionnaires to assess isoflavone intakes or low consumption levels in western populations. Thus, we evaluated the relation between urinary concentrations of isoflavones and risk of incident CHD in middle-aged and older Chinese residing in Singapore.
Methods: The study included 300 incident CHD cases (150 males and 150 females) and 300 matched controls nested in the Singapore Chinese Health Study, a prospective cohort of Chinese adults aged 45-74 years old enrolled in 1993-1998. Cases and controls were randomly selected from participants who provided morning spot urine samples during the first follow-up visit (1999-2004) and were free of CHD/stroke at the time of urine collection. The cases developed myocardial infarction confirmed by medical records or died of CHD up to 2010. The controls did not develop CHD during the follow-up and were matched by sex, dialect group, year of birth, year of recruitment and date of biospecimen collection. Urinary isoflavones were determined by high-performance liquid chromatography. Conditional logistic regression models were used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) with adjustment for potential confounders.
Results: The mean concentration of urinary isoflavones was 5.92 and 5.51 nmol/mg creatinine in cases and controls, respectively. We did not observe significant association between urinary isoflavones and risk of CHD; the ORs (95% CIs) for the 2nd and 3rd tertiles were 0.88 (0.56-1.40) and 0.95 (0.62-1.43), respectively, compared to the 1st tertile (P-trend=0.95). No significant associations were found in men or women; the respective ORs (95% CIs) were 0.47(0.22-1.01) and 0.74 (0.39-1.41) in men; and 1.56 (0.81-3.00) and 1.23 (0.66-2.28) in women. No significant associations were observed for any of the individual isoflavone metabolites in urine: daidzein, geistein, glycitein and equol.
Conclusions: The present study did not find a statistically significant association between urinary concentrations of total isoflavone or its metabolites and risk of incident CHD.
Author Disclosures: M. Talaei: None. R.M. van Dam: None. J. Yuan: None. B. Lee: None. C. Ong: None. W. Koh: None. A. Pan: None.
- © 2014 by American Heart Association, Inc.