Abstract 13451: Prolonged PR Interval is Significantly Associated with Increased Risk of Cardiovascular Diseases and Strokes in a Population-based Cohort Study
Introduction: Recently a community-based cohort study reported that prolonged PR interval has been associated with increased risks of atrial fibrillation, pacemaker implantation, and all-cause mortality. However, prognostic importance of prolonged PR interval is still controversial.
Hypothesis: We assessed the hypothesis that prolonged PR interval is associated with incidence of strokes and cardiovascular diseases (CVDs) in a Japanese urban population.
Methods: We followed up 5,425 participants (aged 30-83 years; 47% men) without prior CVDs, who attended a routine examination. Single 12-lead electrocardiogram recordings and biochemical examinations were taken in the baseline survey from 1989 to 1994. The ECG findings were independently evaluated by 2 trained medical doctors according to the MC (Minnesota code) criteria.
Prolonged PR interval was defined as PR≥ 220ms (Minnesota Code 6-3). Compared with participants without prolonged PR interval, cox regression analysis was carried out to estimate the hazards ratios (HRs) and 95% confidence intervals (CIs) of CVD after adjusting for other risk factors.
Results: Prevalence of prolonged PR was 0.33% at baseline. During an average follow-up period of 13.1 years, 421 CVDs (254 in men, 167 in women) consisting of 180 coronary heart diseases (CHDs), 241 strokes, and 144 cerebral infarctions were observed. After adjustment of age, sex, body mass index, hypertension, hypercholesterolemia, diabetes, current smoking, current alcohol drinking, and estimated glomerular filtration rate, HRs of all CVDs, CHDs, strokes and cerebral infarctions were 2.98 (95% CIs, 1.22-7.31; p=0.02), 1.57 (95% CIs, 0.22-11.42; p=0.65), 3.90 (95% CIs, 1.42-10.72; p<0.01), and 3.96 (95% CIs, 1.23-12.79; p=0.02), respectively. Although there was no significant difference of average age between PR prolongation group and reference group (58.1±17.3 and 54.5±13.0; p=0.24) at baseline, the age of those with prolonged PR interval who developed cerebral infarction in this cohort study was over 70 years old at baseline.
Conclusions: This prospective cohort study is the first report that prolonged PR interval is significantly associated with increased risk of all CVDs and, especially strokes.
Author Disclosures: T. Kobayashi: None. M. Watanabe: None. Y. Kokubo: None. S. Kamakura: None. K. Kusano: None. Y. Miyamoto: None.
- © 2014 by American Heart Association, Inc.