Abstract 13114: Telomere Length is Not Associated With Known Cardiovascular Risk Factors in Older Patients (≥75 Years) with Acute Coronary Syndrome Treated by Invasive Strategy
Background: Telomere length (TL) is emerging as a promising biomarker for cardiovascular ageing. In younger patients (≤65 years), TL is associated with risk factors for acute coronary syndrome (ACS) such as gender, age, hypertension, smoking status, and diabetes, and is also predictive of prognosis following ACS. However, it is not known whether these associations are still present in older patients with ACS, as telomere attrition slows with age. It is also not known whether frailty, an independent predictor of poor outcome following ACS in older patients, is associated with TL.
Methods: We evaluated 54 consecutive ≥75 year old patients admitted for invasive management of non-ST elevation ACS. TL was measured by quantitative real-time polymerase chain reaction using DNA extracted from peripheral blood mononuclear cells (PBMC). Frailty was assessed using the Fried criteria and categorised as robust, pre-frail or frail.
Results: Baseline characteristics are shown in Table 1. The mean age was 81.3±4 years and 51.9% were male. The mean TL was 2468.7±770 base pairs (bp). There was no correlation between age and TL (r= -0.031, p=0.823) and no significant difference in mean TL between males (2384±670.2bp) and females (2581.8±866.4bp, p=0.416). There were no significant differences between tertiles of TL and smoking status, hypertension, diabetes, previous ischemic heart disease or previous cerebrovascular disease. There were no significant differences between tertiles of TL and frailty status.
Conclusion: PBMC TL in this high risk cohort is not associated with age, sex, cardiac risk factors or frailty. TL in this age group may no longer be a predictor of cardiovascular ageing due to its slow attrition. Larger, longitudinal studies are needed to evaluate the trajectory of TL in this age group, and whether it is associated with long-term outcomes following ACS.
Author Disclosures: M. Sharifpour: None. H. Sinclair: None. M. Veerasamy: None. J. Tee: None. D. Neely: None. C. Martin-Ruiz: None. W. Qiu: None. V. Kunadian: None.
- © 2014 by American Heart Association, Inc.