Abstract 12974: Long Sleep Duration and B-Type Natriuretic Peptide: Determinants of Left Ventricular Mass Index in the Japanese at High-Risk of Cardiovascular Disease
Introduction: Recently, several studies have reported that long sleep duration was independently associated with left ventricular mass (LVM). On the other hand, B-type natriuretic peptide (BNP) was shown to be a useful indicator for the severity of essential hypertension, detecting cardiac hypertrophy. In this study, the relationships among self-reported sleep duration, BNP and LVM index (LVMI) were investigated in the Japanese at high-risk of cardiovascular disease. In addition, we investigated whether antihypertensive treatment moderated these relationships or not.
Hypothesis: Sleep duration would be associated with LVMI interacted by antihypertensive treatment.
Methods: Among 4310 patients with one or more cardiovascular risks recruited for the Japan Morning Surge-Home Blood Pressure Study, transthoracic echocardiography and BNP measurement were performed in the 1534 patients (65.7 years old, male 48.4%). A self-administered questionnaire included items on daily sleep duration was used.
Results: According to the sleep duration (6h or less, >6 to 8h <, 8h or more per night), significant associations of sleep duration were observed with LVMI (98.2 vs 97.1 vs 102 g/m2, p<0.001). In the multiple regression analysis adjustment for confounders including age, gender, body mass index, total cholesterol and clinic systolic blood pressure (SBP), long sleep duration (8h or more per night) (B: 3.3, 95%CI: 0.3-6.3, p<0.05) and BNP (B: 0.11, 95%CI: 0.09-0.14, p<0.0001) were significantly positively associated with LVMI. Significant interactions were found between long sleep duration and BNP for LVMI (p<0.05) in the group without calcium channel blockers (p<0.05), angiotensin receptor blockers (ARBs) (p<0.05), or diuretics (p<0.05), while these interactions were not found in that without beta-blockers.
Conclusions: Long sleep duration and BNP were significant indicators of increased LVMI in the high-risk Japanese population. In those without CCBs, ARBs or diuretics, long sleep duration, interacted by BNP served as a strong marker for LVMI. CCBs, ARBs or diuretics might be important not to aggravate the hypertensive target organ damage caused by long sleep duration.
Author Disclosures: M. Nagai: None. S. Niijima: None. S. Hoshide: None. M. Takahashi: None. M. Shimpo: None. K. Kario: None.
- © 2014 by American Heart Association, Inc.