Abstract 12962: Nonsustained Ventricular Tachycardia is Independently Associated With Lower Cognitive Executive Function: The Atherosclerosis Risk in Communities (ARIC) Study
Background: Atrial fibrillation is associated with greater cognitive decline and increased risk of dementia. Little is known about whether other arrhythmias, such as nonsustained ventricular tachycardia (NSVT), are associated with cognition. We aimed to assess the cross-sectional association of NSVT with cognitive test scores in the ARIC study, a community-based prospective cohort study in the USA.
Methods: We included 325 (mean age, 76.9 ± 5.2 years; 52.9% women) participants who underwent cognitive tests (Table) and ≥2 days of heart rhythm recording using the Zio®Patch (a non-invasive, leadless, 2-week ambulatory continuous ECG recording device by iRhythm Techonologies, Inc.) in July 2013-March 2014. NSVT was defined as a wide complex tachycardia >4 beats with a rate >100 bpm. We used multivariable linear regression to assess the association of NSVT with standardized z-scores of cognitive tests.
Results: The mean wear and analysis time of the Zio®Patch were 13.1 ± 2.1 and 12.7 ± 2.3 days, respectively. There were 84 (25.8%) participants with NSVT recorded. The table shows that presence of NSVT was independently associated with lower DSS, but not MMSE, DWR, AN, and CTP.
Conclusions: Presence of NSVT is independently associated with lower cognitive function, specifically executive function. Given the number of cognitive tests that were evaluated, our finding will need to be replicated in other independent samples and confirmed prospectively. Further research is warranted to elucidate its mechanism.
Author Disclosures: L.Y. Chen: None. S.K. Agarwal: None. F.L. Lopez: None. R.F. Gottesman: None. L.R. Loehr: None. E.Z. Soliman: None. T.H. Mosley: None. A.R. Folsom: None. J. Coresh: None. A. Alonso: None.
- © 2014 by American Heart Association, Inc.