Abstract 12881: Increased Stiffness of Aorta is Related to the Decreased Myocardial Flow Reserve Assessed by NH3 Myocardial Perfusion PET in Patients With Hemodialysis
Introduction: In patients with compliant aorta, reflective wave from the peripheral artery arrives at the aortic root at diastolic phase. In patients with stiff aorta, reflective wave arrives earlier in the central aorta so that the diastolic pressure decreases. In this context, aortic stiffness may affect myocardial flow reserve. The patients with hemodialysis tend to have stiff aorta with calcifications. Here, we investigate the relation between myocardial flow reserve (MFR) assessed by NH3 myocardial perfusion PET and aortic stiffness in patients with hemodialysis.
Methods: Forty-five patients with hemodialysis enrolled to this study. After 15 minutes rest, brachial-ankle pulse wave velocity (baPWV) was measured using BP-203 (Omron Japan). Patients who have significant decreased ABI (<1.0) were excluded because of the possible stenosis in femoral arteries. Patients who has significant stenosis in coronary artery assessed by CT coronary angiography were also excluded. Total 29 patients were further examined in this study. The NH3-PET was done during rest and during adenosine infusion. Myocardial flow reserve (MFR) was defined as the ratio of hyperemic to basal coronary velocity. Quantitive myocardial perfusion was calculated with SIEMENS MBF software.
Results: Subjects with decreased MFR (< 2.0) had significantly higher baPWV (2198 cm/s vs 1682 cm/s; p<0.001). There were significant negative correlation between MFR and baPWV (r=-0.54, p<0.01).
Conclusions: In patient with hemodialysis, stiffness of aorta might be an important determinant of myocardial flow reserve.
Author Disclosures: T. Yamamoto: None. M. Yano: None. K. Suga: None. M. Matsuzaki: None.
- © 2014 by American Heart Association, Inc.