Abstract 12824: Comparison of Tissue Doppler-Derived and Speckle Tracking-Derived Parameters for the Estimation of Left Ventricular Filling Pressure: A Multicenter Study in Japan
Background: We conducted a multicenter study in Japan to compare tissue Doppler echocardiography-derived and speckle tracking echocardiography (STE)-derived parameters of left ventricular (LV) diastolic function for the estimation of LV filling pressure.
Methods: Seventy-eight patients (age 59±14 years, 59 male) with structural heart diseases including angina pectoris (n=34), old myocardial infarction (n=15), dilated cardiomyopathy (n=13), hypertrophic cardiomyopathy (n=8), and hypertensive heart disease (n=8) were studied according to the same protocol in 5 university hospitals in Japan. LV mean diastolic pressure (MDP) was measured by using a micromanometer-tipped catheter. Early-diastolic mitral annular velocity (e′) was measured at septal and lateral side of the annulus and averaged, and the ratio of early-diastolic transmitral velocity to e′ (E/e′) was calculated. Global longitudinal strain was measured using STE in 3 apical views and averaged on a frame-by-frame basis to construct a time-strain curve as well as a time-strain rate (SR) curve. Then, the absolute value of peak longitudinal strain (LS), early-diastolic peak SR (LSRE), and that during isovolumic relaxation (IVR) period (LSRIVR) were measured. Similarly, peak circumferential strain (CS), early-diastolic peak circumferential SR (CSRE), and that during IVR (CSRIVR) were measured from 3 short-axis views.
Results: E/e′ weakly correlated with MDP (r=0.50, p<0.001). E/LSRIVR and E/CSRIVR did not correlate with MDP, whereas there was a significant but weak correlation between E/LSRE and MDP (r=0.50, p<0.001) or between E/CSRE and MDP (r=0.41, p<0.001). In contrast, there was a good correlation between E/LS and MDP (r=0.70, p<0.001) or between E/CS and MDP (r=0.62, p<0.001). Especially, the correlation between E/LS and MDP was statistically better than that between E/e′ and MDP (p<0.01).
Conclusions: STE-derived longitudinal parameters better correlated with MDP than circumferential parameters. Especially, E/LS was better than E/e′ for estimating LV filling pressure.
Author Disclosures: T. Hayashi: None. S. Yamada: None. M. Nakabachi: None. H. Iwano: None. M. Sakakibara: None. K. Okada: None. D. Murai: None. H. Nishino: None. K. Kusunose: None. K. Watanabe: None. T. Ishizu: None. K. Wakami: None. H. Yamada: None. K. Dohi: None. Y. Seo: None. N. Ohte: None. T. Mikami: None. H. Tsutsui: Research Grant; Significant; MSD, Astellas, Ohtsuka, Shionogi, Daiichi-sankyo, Tanabe-Mitsubishi, Novartis, Pfizer. Honoraria; Significant; Daiichi-Sankyo, Tanabe-Mitsubishi, Pfizer, MSD.
- © 2014 by American Heart Association, Inc.