Abstract 12809: Pre-Procedural Aortic Valve Area Predicts Degree of Thrombocytopenia Following Trans-Catheter Aortic Valve Implantation
Introduction: Thrombocytopenia (TP) has been described following percutaneous balloon aortic valvuloplasty (BAV) and surgical aortic valve replacement (SAVR), but only recently noted following trans-catheter aortic valve implantation (TAVI). While transient, the TP may be severe leading to increased bleeding.
Methods: We conducted a retrospective analysis of all patients undergoing TAVI with either a 23mm or 26mm Edwards Sapien valve (Edward Lifesciences, Irvine, California) at our institution.. The effect of multiple independent variables on % platelet change after TAVI were analyzed using paired and unpaired T-tests, two-way ANOVA, and Chi-square tests as appropriate. Platelet % change was correlated with aortic valve area using Pearson correlation. A p-value of <0.05 was considered statistically significant.
Results: A total of 33 patients (54.5% male, median age 79.3, mean valve area 0.76 cm2) were included in this analysis. The degree of aortic valve stenosis significantly correlated with post-procedural TP severity (Figure 1). The degree of TP post TAVI was found to be significantly lower in those patients who received BAV prior to their TAVI procedure (p < 0.01).
Conclusions: Post-TAVI TP correlates with the degree of pre-procedure aortic stenosis. Given the need for peri-procedural anticoagulation and post-procedural dual antiplatelet therapy, this finding can help identify patients at risk for symptomatic TP and may help guide post procedure antiplatelet therapy. Further studies are needed to elucidate the underlying mechanism.
Author Disclosures: E. Retzer: None. C. Tabit: None. J. Paul: None. S. Nathan: None. J. Friant: None. V. Jeevanandam: None. H. Balkhy: None. T. Ota: None. R. Lang: Speakers Bureau; Modest; Phillips. Consultant/Advisory Board; Modest; Phillips. K. Dill: None. A. Shah: None.
- © 2014 by American Heart Association, Inc.