Abstract 12756: Mc4r Genotype and 2-Year Change in Appetite in Response to Weight-loss Diets: The Pounds Lost Trial
Hypothesis: Obesity associated melanocortin 4 receptor gene (MC4R) plays a pivotal role in the regulation of appetite, eating behavior and energy expenditure, as well as body weight. We examined whether GWAS-identified, obesity related MC4R genotype modified the long-term changes in appetite, food craving and hunger in response to weight loss diet interventions in a randomized controlled trial.
Methods: We genotyped MC4R rs7227255 in 737 overweight adults in the 2-year Preventing Overweight Using Novel Dietary Strategies (Pounds Lost) trial and assessed four appetite related traits including cravings, fullness, hunger, and prospective consumption.
Results: We found that dietary protein significantly modified genetic effects on changes in appetite, food cravings, and hunger at 24 m after adjustment for age, sex, ethnicity, baseline body mass index, weight change, baseline value for perspective phenotype (P for interaction=0.02, 0.008, and 0.03). The A allele was associated with a greater increase in appetite (β=0.10, P=0.05) and food cravings (β =0.13, P=0.008) among the participants with high protein diet intake. MC4R rs7227255 did not modify effects of fat and carbohydrate intakes on the appetite measures.
Conclusions: Our data suggest that individuals with the MC4R rs7227255 A allele might obtain more increases in appetite and food cravings by choosing a higher protein weight-loss diet.
Author Disclosures: T. Huang: None. Y. Shen: None. Y. Zheng: None. Y. Li: None. G.A. Bray: None. D.A. Williamson: None. F.M. Sacks: None. L. Qi: None.
- © 2014 by American Heart Association, Inc.