Abstract 12691: The Combination of Depression and Diabetes is Associated With Short-Term Risk of Death and Myocardial Infarction Among Patients Undergoing Angiography for Acute Coronary Syndrome
Background: Depression and diabetes have been shown to be associated with adverse cardiovascular (CV) events. However, whether there is an increased risk when both conditions are present is unknown.
Methods: Patients of the Intermountain Heart Collaborative Study were studied if they underwent angiography for acute coronary syndrome (ACS) and had no prior history of CV disease (no CAD [coronary artery disease], MI [myocardial infarction], stroke, or heart failure). Patients were stratified based on their diabetes and depression status: none, diabetes only, depression only, and diabetes and depression. Multivariable Cox hazard regression was utilized to evaluate the association of diabetes/depression groups to death and MI at 30 days, 6 months, and 1 year.
Results: A total of 4,321 (62.7% male; 61.3±12.9 years) patients were studied. The distribution of patients within each diabetes/depression category was: no depression or diabetes: 74.9% (3,236), diabetes only: 18.5% (800), depression only: 4.4% (192), diabetes and depression: 2.2% (93). A total of 46.2% presented with an MI and 61.4% were diagnosed with CAD. Those with both a diabetes and depression diagnosis were at greater risk of short-term death and, in particular, MI (Table).
Conclusion: Among those without a history of CV disease undergoing angiography for ACS, the presence of both diabetes and depression indicated a higher risk of short-term death and, in particular, incident MI, than either one alone or neither diagnosis. Such patients may need greater care and evaluation following angiography for ACS in an effort to reduce short-term morbidity and mortality.
Author Disclosures: H.T. May: None. S. Knight: None. J.L. Anderson: None. B.D. Horne: None. V.T. Le: None. T.L. Bair: None. J.B. Muhlestein: None.
- © 2014 by American Heart Association, Inc.