Abstract 12446: Association of the Red Cell Distribution Width--A Component of the Intermountain Mortality Risk Scores--With In-Hospital Mortality in PCI Patients
Background: Post-hospitalization mortality is predicted by the red cell distribution width (RDW) in both CV and non-CV subjects. The Intermountain Mortality Risk Scores (IMRS) are sex-specific tools for 30-day mortality stratification composed of RDW and other Complete Blood Count (CBC) and/or basic metabolic profile (BMP) components. Whether RDW or IMRS predict in-hospital mortality is unknown.
Methods: Patients were included if treated by PCI at Intermountain Healthcare (males: N=6,007, females: N=2,165). In-hospital all-cause mortality was the primary endpoint (IMRS was derived for 30-day mortality). Secondary endpoints included hospital length of stay (LOS) and 30-day mortality. Logistic regression adjusted for age, in-hospital medications, HAS-BLED score, and (for RDW analyses) BMP and CBC components.
Results: The RDW predicted in-hospital mortality in both males and females (Table), and 30-day mortality in males (weakly in females). IMRS (using CBC only and CBC+BMP) strongly predicted in-hospital and 30-day mortality (Table). IMRS also predicted LOS for males (p<0.0001, β=0.299, CI=0.274, 0.323) and females (p=0.010, β=0.341, CI=0.081, 0.601).
Conclusions: RDW and IMRS predicted in-hospital mortality, even after multivariable adjustment. Early in-hospital use of IMRS may improve personalization of medical care through use of commonly-ordered, inexpensive, electronically-available admission labs. Whether use of IMRS improves in-hospital outcomes requires future randomized trials.
Author Disclosures: B.D. Horne: None. D.L. Lappé: None. R.O. McCubrey: None. H.T. May: None. S. Knight: None. V. Le: None. T.L. Bair: None. J.B. Muhlestein: None. J.L. Anderson: None.
- © 2014 by American Heart Association, Inc.