Abstract 12371: The Association Between Urinary Calculi and Increased Future Cardiovascular Events
Introduction: Although accumulating evidence suggests urinary calculi may increase the risk of cardiovascular disease (CVD), the number of longitudinal studies linking urolithiasis to cardiovascular events is limited.
Hypothesis: We investigated the association between urinary calculi and the risk of development of myocardial infarction (MI) and/or stroke in a nationwide, population-based cohort database in Taiwan.
Methods: Our analyses were conducted using information from a random sample of 1 million people enrolled in the nationally representative Taiwan National Health Insurance Research Database. A total of 81,546 subjects aged 18 years or above, including 40,773 subjects diagnosed with urinary calculi during the study period and a propensity score-matched 40,773 subjects without urinary calculi were enrolled in our study.
Results: During a 10-year follow-up period, 501 MI events (0.61%) and 1,295 stroke events (1.59%) were identified. By comparison, the urinary calculi group had a higher incidence rate of MI occurrence (11.79 vs 8.94 per 104 person-years) and stroke (31.41 vs 22.45 per 104 person-years). Cox proportional hazard regression model analysis showed that development of urinary calculi was independently associated with higher risk of developing future MI (HR, 1.31; 95% CI, 1.09-1.56, p=0.003), stroke (HR, 1.39; 95% CI, 1.24-1.55, p<0.001), and total cardiovascular events (HR, 1.38; 95% CI, 1.25-1.51, p<0.001).
Conclusions: Urinary calculi were associated with an increased risk of future cardiovascular events.
Author Disclosures: C. Hsu: None. P. Huang: None. H. Leu: None. J. Chen: None. S. Lin: None.
- © 2014 by American Heart Association, Inc.