Abstract 12363: Tracking of Central and Upper Limb Systolic Pressure Over the Normal Human Lifespan
Recent studies address the tracking of brachial cuff Systolic Pressure (SP) over segments of life and separately in pediatric populations to age 18 and adult populations from age 25 to 75+ years. There has been no attempt to link the two populations and sporadic studies only on central aortic pressure over long spans, and no explanation on the curious changes in brachial pressures in childhood, adolescence and young adult life.
In this study, we attempt to describe changes in brachial and central aortic SP over the entire life span, to account for the changes and seek their cause and underlying mechanism.
We considered 2 studies of brachial SP in children [1,2], and 3 in adults [3-5], linking pediatric and adult populations with another , and children with neonates in another . Central aortic SP was generated by subtracting estimated amplification at different ages from the peak of upper limb SP using the methods of two commercial systems (use of transfer function in adults , SphygmoCor, and detection of a second systolic wave in, Omron HEM-9000AI). In adults, the two methods give comparable results [8,9].
Upper limb SP rises steeply from birth, less steeply to age 14 when peak body height is attained in girls. Over age 14, SP in males continue to rise to age 20 where growth stops and where after there is only a gradual rise to age 70+, but a continuing higher SP compared to females. For central aortic pressure, there is more gentle rise in childhood and little difference between males and females throughout life. Changes over the whole life are nearly linear for central pressure. A linear rise of central pressure during life is attributable to increase in arteriolar resistance, cardiac output and aortic stiffness. Changes in brachial pressure are more marked and attributable to change in growth and development, and with gender, as well as hemodynamic factors.
Author Disclosures: A. Adji: None. M.F. O’Rourke: Ownership Interest; Significant; AtCor Medical. A. Avolio: None.
- © 2014 by American Heart Association, Inc.