Abstract 12318: Prevalence of Atrial Fibrillation in Patient With Celiac Disease
Background: Inflammation is an established risk factor for Atrial Fibrillation (AF). Celiac Disease (CD) is a systemic autoimmune inflammatory disease. Given the nature of the CD, this group could be at high risk for developing AF. We aim to evaluate the prevalence of atrial fibrillation in patients with Celiac disease.
Methods: Electronic health records (01/1999 to 09/2013) from 13 different healthcare systems were obtained utilizing a HIPAA-compliant, patient de-identified web application (Explore; ExplorysInc). Among a total of 22, 385,340 patients, 24,530 were diagnosed with CD. The remaining 22,360,810 patients without CD served as the control group. The demographics and comorbidities are abstracted for comparison.
Results: There was a significantly higher prevalence of AF among CD compared to those without CD [5.6 % vs. 2.8%, p <0.0001)] with the odds ratio being 2.04 (95% CI 1.9 to 2.2). After excluding the patients with coronary artery disease in both groups, the prevalence of AF was still higher among 2.9 % in celiac disease group compared to control group (2.9 % vs. 1.4%, p <0.0001) with odds ratio being 2.05 (95% CI 1.9 to 2.2). Patient characteristics are compared in table 1.
Conclusions: There was a two fold increase in the prevalence of AF in patients with celiac disease compared to those of control group , which could well be due to the autoimmune disease causing systemic inflammation. Further prospective studies are needed to study the association in detail.
Author Disclosures: D.J. pattanshetty: None. R. Gajulapalli: None.
- © 2014 by American Heart Association, Inc.