Abstract 12276: Favorable Cardiovascular Risk Profile at Young/Middle Ages and 39-Year Progression of Major and Minor Electrocardiographic (ECG) Abnormalities - The Chicago Healthy Aging Study (CHAS)
Methods: Using data from CHAS, we assessed the association of favorable CVD risk profile, i.e., low risk (LR) at baseline (1967-73) with ECG major or minor abnormality progression 39 years later (2007-10). LR status was defined as SBP/DBP ≤120/ 80 mmHg and no antihypertensive medication, total cholesterol <200 mg/dl and no lipid-lowering medication, not smoking, BMI <25 kg/m2, and no diabetes. Minnesota code criteria were used to define minor and major ECG abnormalities.
Results: There were 1,393 participants baseline ages 24-45 (mean age was 71.3 years at follow-up), free of baseline major ECG abnormalities and MI, 28% women, 9% blacks, 20% LR. At follow-up, 21% developed ≥ 1 major ECG abnormalities, and 58% developed ≥ 1 minor ECG abnormalities. With multivariable adjustment (see Table), persons with baseline LR were less likely to develop major ECG abnormalities than other groups. For example, compared to those with 2+RFs, odds for the progression of any major ECG abnormalities were lower by 49%, 36%, and 25%, respectively, in persons with LR, 0 RF, and 1RF (P-trend = 0.004). Findings were similar for the progression of most frequent major or minor ECG abnormalities (P-trends <0.05), except for the progression to any minor ECG abnormalities (P-trend = 0.349).
Conclusion: Favorable RF profile earlier in life is associated with lower ECG abnormality progression at older age. These findings underscore the benefit of having LR profile at younger ages in preventing future CVD.
Author Disclosures: T.T. Vu: None. M. Daviglus: None. K. Liu: None. D.B. Garside: None. D.M. Lloyd-Jones: None.
- © 2014 by American Heart Association, Inc.