Abstract 12243: Outcome in Takotsubo Cardiomyopathy: Not as Favorable as Expected?
Introduction: Prognosis of patients with Takotsubo cardiomyopathy (TTC) is generally thought to be favorable. However, the initial presentation can be accompanied by various fatal complications and currently available outcome data are sparse. Therefore, the aim of the present study was to determine short-term and long-term mortality in a large cohort of patients with TTC.
Methods: A total of 177 patients presenting with TTC were matched for age and gender with 177 ST-elevation myocardial infarction (STEMI) patients. Clinical follow-up was conducted with a standardized telephone follow-up and all events were centrally adjudicated.
Results: Follow-up was available in 96.6% of patients after a median of 3.4 years. During the follow-up period, all-cause mortality was significantly higher in TTC patients as compared to the matched STEMI cohort (25.0% versus 16.1%, relative risk [RR] 1.55, 95% confidence interval [CI] 1.01 to 2.39, p=0.04). Cardiovascular mortality did not differ between the study groups. 28-day mortality was 7.1% in patients with TTC compared to 5.7% in patients with STEMI (RR 1.24, 95% CI 0.55 to 2.80, p=0.60). 1-year mortality was numerically higher in the TTC group (14.3% versus 8.6%) without reaching statistical significance (RR 1.66, 95% CI 0.90 to 3.05, p=0.10). 5 patients experienced TTC recurrence during follow-up (3.9%).
Conclusions: Short-term and long-term mortality in patients presenting with TTC are higher than generally expected and at least comparable to mortality rates in patients with STEMI.
Author Disclosures: T. Stiermaier: None. S. Desch: None. G. Schuler: None. H. Thiele: None. I. Eitel: None.
- © 2014 by American Heart Association, Inc.