Abstract 12186: Correlations Between Sleep Disordered Breathing Indexes and Cardiac Functional Parameters in Patients With Chronic Heart Failure
Background and Purpose: High prevalence of sleep disordered breathing (SDB) in patients with chronic heart failure (CHF) was reported. In general, apnea hypopnea index (AHI) is used as a severity of SDB index. On the other hand, it was reported there was not good correlation between AHI and prognosis in CHF patients with SDB. The purpose of this study was to investigate the correlations between cardiac functional characteristics and indexes of SDB severity [AHI, 3% oxygen desaturation index (ODI), and averaged time desaturation summation index (TDSI)] in CHF patients.
Methods: One hundred thirty-six consecutive CHF patients, who were hospitalized from June 2012 to March 2014, were screened at their stable phase. Sleep studies were performed by in-hospital overnight full polysomnograpy (PSG). The following equation was used to determine TDSI. TDSI=total sleep time x (100-mean oxygen saturation).
Results: The mean age was 68±14 years, and 81 men. Underlying etiology was ischemic cardiomyopathy (ICM) in 33 patients (24%), non-ICM in 64 (47%), and others in 39 (29%). Patients presented with an average NYHA class of 2.2±0.7 and a left ventricular ejection fraction (LVEF) of 46.9±17.9%. 73% of patients had obstructive sleep apnea (OSA) and 15% central sleep apnea (CSA). There was a statistical significant correlations between AHI and 3%ODI (r=0.907), between AHI and TDSI (r=0.438), and between TDSI and 3%ODI (r=0.514). There were no significant correlations between each index and cardiac functional parameters (BNP, LVEF, pulmonary arterial pressure, DcT, and E/e’). In 46 patients with LVEF<45%, there were also no significant correlations between these indexes and parameters. In 14 patients with CSA, there was a statistical significant correlations between AHI and 3%ODI (r=0.819), but no significant correlations between other indexes. Also, there were no significant correlations between these indexes and each cardiac function parameter.
Conclusions: In stable CHF patients, there were no significant correlations between SDB indexes (AHI, 3%ODI, and TDSI) and cardiac function parameters. These results indicate that we need to investigate more useful SDB indexes which reflect accurate pathophysiological conditions of patients with CHF.
Author Disclosures: T. Nakashima: Other Research Support; Significant; TEIJIN PHARMA LIMITED. T. Ohkusa: Other Research Support; Significant; TEIJIN PHARMA LIMITED. T. Nao: Other Research Support; Significant; TEIJIN PHARMA LIMITED. N. Harada: None. Y. Wada: None. T. Ueyama: None. S. Kobayashi: None. Y. Ikeda: None. H. Sawatari: None. A. Chishaki: None. S. Ando: None. M. Yano: None.
- © 2014 by American Heart Association, Inc.