Abstract 12031: Orthostatic Hypotension is an Independent Factor for Ischemic Stoke and Cardiac Death
Emerging evidence showed orthostatic hypotension (OH) is associated with increased risk of adverse cardiovascular (CV) events, but the data of large clinical trails was limited. The present study aims to exam the relationship between OH and CV events in middle-age Asian population.
METHOD: A national health insurance program has been implemented in Taiwan since 1995. We used system sampling database from 2000 to 2011, with a total of 1,000,000 subjects, and enrolled subjects with OH above 18 years old. The control group was matched with the study subjects in a ratio of 1:10, and in terms of age, sex, and cormobidities.
RESULT: Overall 13,486 subjects were identified, included 1,226 patients with OH. Kaplan-Meier analysis demonstrated a tendency of development of adverse CV events in subjects with OH. After multivariate Cox model adjustment, individuals with OH have significant increased risk in ischemic stroke (HR 1.403; 95% CI 1.089-1.806, p=0.009), all-cause mortality (HR 1.351; 95% CI 1.053-1.732, p=0.018), and adverse CV events (HR 1.410; 95% CI 1.180-1.685, p<0.001).
CONCLUSION: OH is independent related to development of ischemic stoke, all-cause mortality, and adverse CV events in Asian population.
Author Disclosures: R. Chou: None. C. Liu: None. T. Chao: None.
- © 2014 by American Heart Association, Inc.