Abstract 11968: Nocturnal Blood Pressure in Young Adults and Cognitive Function in Midlife: The CARDIA Study
Nocturnal blood pressure (BP) is associated with risk for cardiovascular events. However, the effect of nocturnal BP in young adults on cognitive function in midlife remains unclear.
We used data from the ambulatory BP monitoring substudy of the Coronary Artery Risk Development in Young Adults (CARDIA) Study, including 224 participants (mean age 30 years, 45% men, 63% African Americans) followed for 20 years (6 visits). At the 20-year follow-up, the Stroop test (higher score indicates worse executive function), Digit Symbol Substitution Test (DSST, lower score indicates worse psychomotor speed), and Rey Auditory Verbal Learning Test (RAVLT, lower score indicates worse verbal memory) were assessed.
Baseline mean office, daytime, and nocturnal BP were 109/73mmHg, 120/74mmHg, and 107/59mmHg, respectively. Nocturnal BP dipping, calculated as (nocturnal systolic BP [SBP]-daytime SBP)х100/daytime SBP, was divided into quartiles (Q1;-39.3% to -16.9%, Q2;-16.8% to -13.2%, Q3 [reference];-13.1% to -7.8%, and Q4;-7.7% to +56.4%).
Cognitive function score according to the quartile of nocturnal SBP dipping is shown in Figure. In linear regression models, the least nocturnal SBP dipping (Q4 vs. reference) and higher nocturnal diastolic BP (DBP) level were associated with worse Stroop scores, with adjustments for demographic and clinical characteristics, and cumulative exposure of BP during follow-up (β [standard error]: 0.37[0.18] and 0.19[0.07] respectively; all P<0.05). Neither DSST nor RALVT was associated with either nocturnal BP dipping or nocturnal SBP/DBP levels.
Among healthy young adults, less nocturnal SBP dipping and higher nocturnal DBP levels were associated with lower executive function in midlife, independent of long-term office BP levels. Nocturnal BP measures in young adults could be potentially useful to identify those who may be at risk for developing lower cognitive function in midlife.
Author Disclosures: Y. Yano: None. H. Ning: None. P. Muntner: None. J. Reis: None. D. Calhoun: None. A. Viera: None. D. Levine: None. J. David: None. D. Shimbo: None. K. Liu: None. P. Greenland: None. D. Lloyd-Jones: None.
- © 2014 by American Heart Association, Inc.