Abstract 11965: Novel Simple and Accurate Quantitative Endothelial Function Measurements Using Brachial Artery Vascular Volume Elastic Modulus With Automated Oscillometric Approach
Background: Simple and automated arterial endothelial function measurements are desirable for atherosclerosis risk assessments. Vascular elastic modulus (VE) is uninfluenced by blood pressure and potentially is linked to endothelial function. However, previous VE measurements have been complex or invasive. Recently, we developed a novel modality of automated oscillometric method to measure a brachial artery’s VE. We aimed to investigate whether VE reflected endothelial dysfunction related to chronic kidney disease (CKD). We also evaluated the reliability of new automated VE methods.
Methods: 13 moderate-to-severe CKD pts (mean estimated glomerular filtration rate [eGFR] 29.3±25.7 mL/min/1.73m2) and 16 controls were studied. Rest VE and estimated arterial cross sectional area (eA) in brachial artery were measured by new automated oscillometric detector. eA was estimated using pressure-volume curves and VE was defined as follows [VE = ΔPressure/ (100XΔarea / Area) mmHg/%]. Controls repeated eA and VE measurements. Using ultrasound (US), we measured the brachial artery diameter at rest and during reactive hyperemia [flow mediated dilatation (FMD) with endothelial-dependent dilatation].
Results: Absolute value of eA was correlated with US measured arterial diameter (R=0.78, P<0.001). Rest eA and VE showed good reproducibility (eA: ICC = 0.88, VE: ICC = 0 .78). CKD had lower FMD than control (4.46±3.06 vs 7.88±4.04 %, P=0.018). CKD also showed attenuated VE as compared to control (1.09±0.25 vs 0.80±0.16 mmHg/%, P=0.002). VE was negatively correlated with eGFR (r=-0.51, P=0.005) and %FMD (r=-0.38, P=0.04).
Conclusions: This new automated vascular elastic modulus measurement reliably detected vascular dysfunction related to CKD. Vascular dysfunction depicted with this approach closely correlated with FMD. Thus, this simple automated oscillometric measurement may be useful for detecting vascular anatomical information and endothelial dysfunction.
Author Disclosures: K. Yoshinaga: Research Grant; Modest; A&D Co, Ltd.. Y. Tomiyama: None. S. Fujii: None. S. Nishio: None. N. Matsuoka: None. N. Ochi: None. C. Katoh: None. M. Inoue: None. M. Nishida: None. Y.M. Ito: None. H. Nishibayashi: Employment; Modest; A&D, Company, limited. N. Tamaki: Research Grant; Modest; A&D, Company, limited.
- © 2014 by American Heart Association, Inc.