Abstract 11909: Changes in Brain Caudate Nuclei Functional Connectivity in Heart Failure
INTRODUCTION: Heart failure (HF) subjects show caudate nuclei injury. The caudate nuclei serve cognitive, learning, memory, and motor functions, which are dependent upon connections to prefrontal, frontal, and limbic sites in order to impact these activities. Whether specific functional connections (FC, interaction ability via white matter connections between brain areas) from the caudate to these brain sites are affected in HF is unknown.
METHODS: We collected resting-state functional MRI data from 17 HF (age 54.4±8.1 years; Females 5; BMI 29.4±5.7 kg/m2; LVEF 0.28±0.07) and 45 controls (age 50.9±7.6; Females 15; BMI 25.1±3.8 kg/m2), using a 3.0 Tesla MRI scanner, and analyzed with SPM8 and MATLAB-based software. Individual correlation maps between left and right caudate seed areas and whole-brain were calculated, converted to z-scored maps and compared with ANCOVA (covariates, age and gender; P<0.05; cluster-corrected).
RESULTS: The right caudate (Fig. 1) showed decreased FC in HF with the medial paracentral lobule (b), precuneus (a), and left cerebellum (e), and increased FC with the right precuneus (c), left precentral gyrus (d), and right postcentral gyrus (g). The left caudate (Figure) showed increased FC in HF with the left insula (h), left precentral gyrus, and left and right postcentral gyrus (f), but no sites with decreased FC, over control subjects.
CONCLUSIONS: Despite injury, both left and right caudate nuclei show increased FC to primary motor and sensory cortices, and the left shows enhanced insular FC in HF. The enhanced FC to motor and parasympathetic regions may reflect compensatory efforts to overcome injured gray matter regions (caudate, insular, and frontal) processes of impaired motor and autonomic regulation, with the diminished cerebellar FC reflecting the motor dis-coordination.
Author Disclosures: M.A. Woo: Research Grant; Modest; NIH/NINR R01NR013625, NIH/NINR R01NR014669. B. Park: Research Grant; Significant; NIH/NHLBI R01 HL113251, NIH/NINR R01NR013625. P.M. Macey: None. G.C. Fonarow: Research Grant; Modest; NIH/NINR R01NR013625, NIH/NINR R01NR009116. R.M. Harper: None. R. Kumar: Research Grant; Significant; NIH/NHLBI R01HL113251, NIH/NINR R01NR013625, NIH/NINR R01NR009116.
- © 2014 by American Heart Association, Inc.